Str and crit are your friend and you'll end up doing silly damage especially using combos.
You can add vit i guess but as there is +100hp xtal not really worth it and on those mini boss things (pink potum, colon commander etc) you most definately wont be tanking them and staying alive.
Skill wise hit pure damage ones safest option, i was curious about a tanky/dps 2 hander taking knight skills for knockback,slow and parry. But with all those unknown skills its hard to know if that would work.
Sonic blade: does obscene things as an aoe skill with a 2 handed sword. At lvl10 the range on it is huge and it crits alot. You have to get used to it, change target options from near to far and take off auto lock(forget the option name in settings, its the last one). You can charge further than the targeted far target so run back a bit get more monsters in line
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For aoe id say the best but you have to be concentrating all the time its not a static aoe on the ground. Whatever is inbetween you and your target gets hit and the width is big with a 2 handed sword. Even if something dodges, guards no problem target a new one run but a bit gather more repeat.
Astute: does really high damage with 2 handed swords but costs 200mp (100mp for 1 handed swords). In a combo: hard hit-astute (with smite) is easily 8k+ on crit. Adding a 3rd skill will remove the massive mp cost of astute with smite.
Spiral air: fun skill but costs soo much MP
, at lvl10 it can do alot of damage and you can keep doing more attacks. If you dont have much mp i'd say pass this one.
Trigger: very good for longer fights, good dmg and increased mp regen.
The other skills at the bottom of the tree are a nice boost, the last one sword mastery is very nice even more damage on those skills
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MP: will be a constant problem and the skills that do the most damage cost alot with a 2 hander :/ 200mp.
Survival skill tree can help or mana recovery in support tree (you have to 1 hit targets for mana recovery to work, when you get hit buff ends and its a 300mp party buff regens a ton of mp though)
Magicians ring helps alot (special+1000mp -25%atk and matk) for farming you'll still 1 hit things. If not take aristocratic ring from quest.
+50mp xtal is also an option and gesphat?? (Ghost boss in sewers) xtal is 150mp 50hp -1%atk and matk.
For quick MP regen when out of combat use libra staff made at blacksmith in sofya, it gives +1000 cspd. When used with magic skill charge at lvl10 its 300mp in 2.5-3s. Changing weapons from 2 handed sword to libra and back.
Equip: currently best weapon is heavy blade, atk 32 (best of heard of) and potential 26+.
Armour is wolf with potential 30+.
Slotted obviously best, 2 slotted even better but extremely hard to get a slot at max atk and potential.
Anyways, hope that helps.
Sorry was a long post